Molecular interactions in pharmaceutical compounds

Molecular interactions between solvent and pharmaceutical compounds in crystallization of polymorphic systems

Polymorphism in pharmaceutical solids is a major issue that has medical, financial and legal implications. There are many thermodynamics and kinetics factors which affect the polymorph selectivity during the crystallization process such as nucleation temperature, supersaturation and type of solvent. Among these parameters, type of solvent is a major kinetic factor that has drawn the attention o...

Molecular modeling of β-cyclodextrin inclusion complexes with pharmaceutical compounds

Ten molecularly diverse compounds, selected on the basis of the standard free energy of complexation with β-cyclodextrin, have been used as training set of molecular docking experiments. After the conformational search of each compound the Molecular Interaction Evaluation (MOLINE) program has been adopted to generate the inclusion geometries. The recognition process has been thermodynamically e...

Pharmaceutical Compounds in the Environment

Ozone Degradation of Iodinated Pharmaceutical Compounds

Thermal analysis of some antidiabetic pharmaceutical compounds.

PURPOSE Thermal behavior of some antidiabetic drugs such as pioglitazone hydrochloride (PTZ), rosiglitazone maleate (RGZ), glibenclamide (GBD) and glimepiride (GMP) has been studied. METHODS Thermogravimetric analysis (TGA), derivative thermogravimetry (DTG) and differential thermal analysis (DTA) techniques were used to study the thermal behavior of the drugs under investigation. RESULTS T...